{"id":6054,"date":"2022-12-07T15:59:18","date_gmt":"2022-12-07T14:59:18","guid":{"rendered":"https:\/\/www.fgw-brandenburg.de\/stammzellbiologie-des-alters\/"},"modified":"2024-09-16T08:52:38","modified_gmt":"2024-09-16T06:52:38","slug":"stem-cell-biology-of-aging","status":"publish","type":"page","link":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/","title":{"rendered":"Stem Cell Biology of Aging"},"content":{"rendered":"\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:55%\">\n<div style=\"height:120px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Prof. Dr. rer. nat. Julia von Maltzahn is FGW Professor for <strong>Stem Cell Biology of Aging<\/strong> at the Brandenburg University of Technology Cottbus-Senftenberg (BTU).<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging and during differentiation. Furthermore, they study the causes for impaired myogenic differentiation in rhabdomyosarcoma. <\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The final goal is the improvement of regeneration of skeletal muscle in age and disease.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column\" style=\"flex-basis:5%\"><\/div>\n\n\n\n<div class=\"wp-block-column\" style=\"flex-basis:40%\">\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/10\/Maltzahn_JuliaVon_Stammzellbiologie_FGW-scaled-e1671188888482.jpg\" alt=\"Prof. Dr. Julia von Maltzahn\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/prof-dr-julia-von-maltzahn\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Prof. Dr. Julia von Maltzahn<\/div>\n    <div class=\"about_person__position\">Dean of Research\/ Head of the Professorship for Stem Cell Biology of Aging<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385526\" class=\"about_person__phone\">phone: +49 (0) 357385526<\/a><a href=\"mailto:julia.vonmaltzahn@fgw-brandenburg.de\" class=\"about_person__email\">julia.vonmaltzahn[at]fgw-brandenburg.de<\/a>  <\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p>Location: B-TU Cottbus-Senftenberg, Universit\u00e4tsplatz 1, 01968 Senftenberg, Office 14E.402<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs\" data-active-tab=\"0\"><ul class=\"wp-block-getwid-tabs__nav-links\"><\/ul>\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Research<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p>Skeletal muscle fulfills a multitude of functions in the organism, among them voluntary movements. Furthermore, skeletal muscle has a remarkable ability to adapt and to regenerate. For instance, the size of myofibers \u2013 the units which are responsible for the movement of skeletal muscle \u2013 can be adapted due to physical exercise or disuse. With increasing age, plasticity of skeletal muscle is reduced concomitant with an altered ability to regenerate.<\/p>\n\n\n\n<p>Muscle stem cells, also called satellite cells, are essential for regeneration of skeletal muscle. Under resting conditions muscle stem cells are quiescent but are activated due to increased muscle activity or damage of skeletal muscle. During regeneration of skeletal muscle the cells proliferate and undergo myogenic differentiation and subsequent fusion resulting in the formation of newly formed myofibers. During aging muscle stem cells and their immediate niche undergo alterations.<\/p>\n\n\n\n<p>Our research group investigates those intrinsic alterations and alterations in the immediate muscle stem cell niche with the aim to identify signaling pathways which are altered during aging to rejuvenate aged muscle stem cells. The final goal of our work is the restoration of homeostasis of muscle stem cells and the treatment of sarcopenia, the age related loss of muscle mass and function.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"673\" height=\"264\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png\" alt=\"Muskelstammzellen auf einer Muskelfaser (Pax7 \u2013 Marker f\u00fcr Muskelstammzellen in rot, Dapi in blau)\" class=\"wp-image-6143\" style=\"width:505px;height:198px\" srcset=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png 673w, https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen-300x118.png 300w\" sizes=\"(max-width: 673px) 100vw, 673px\" \/><\/figure>\n\n\n\n<p class=\"has-small-font-size\">Muscle stem cells on a myofiber (Pax7 \u2013 marker for muscle stem cells in red, Dapi in blue)<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Projects<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h3 class=\"wp-block-heading\">Alterations of muscle stem cells during aging<\/h3>\n\n\n\n<p>We are investigating intrinsic alterations of muscle stem cells and their immediate niche which occur during aging. Thereby we aim for a better understanding of alterations which occur during aging to help develop therapies to improve regeneration of skeletal muscle in the aged.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"678\" height=\"1024\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelveraenderungen_im_Alter-678x1024.jpg\" alt=\"Ver\u00e4nderungen im Muskel mit dem Alter (ver\u00e4ndert nach Henze et al., 2020)\" class=\"wp-image-6152\" style=\"width:509px;height:768px\" srcset=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelveraenderungen_im_Alter-678x1024.jpg 678w, https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelveraenderungen_im_Alter-199x300.jpg 199w, https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelveraenderungen_im_Alter-1017x1536.jpg 1017w, https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelveraenderungen_im_Alter.jpg 1180w\" sizes=\"(max-width: 678px) 100vw, 678px\" \/><\/figure>\n\n\n\n<p class=\"has-small-font-size\">Alterations in muscle stem cells during aging. (modified after Henze et al., 2020)<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Investigation of causes for impaired differentiation of muscle stem cells in the aged<\/h3>\n\n\n\n<p>It is known that induction of myogenic differentiation is impaired during aging. We aim to understand the molecular causes for this reduced ability to differentiate with the goal to improve induction of differentiation in the aged.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Alterations in muscle stem cells due to cancer cachexia<\/h3>\n\n\n\n<p>With increasing age also the likelihood of cancer increases. A large proportion of cancer patients is suffering from cancer cachexia, the cancer related loss of muscle mass and function. Cancer cachexia is associated with a reduced ability to regenerate and impairments in differentiation of muscle stem cells. We are investigating the signaling pathways and molecular mechanisms which cause this impaired differentiation. Thereby we aim to support the development of new therapies to improve regeneration of skeletal muscle in cancer cachexia.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Induction of myogenic differentiation in rhabdomyosarcoma<\/h3>\n\n\n\n<p>Rhabdomyosarcomas are soft tissue sarcomas which mostly manifest in children. They are thought to derive from muscle progenitor cells. Rhabdomyosarcomas can be divided in two major subgroups, the alveolar and the embryonal rhabdomyosarcomas. All rhabdomyosarcoma cells share an impairment in myogenic differentiation. We are investigating the molecular causes for this impaired myogenic differentiation in alveolar and embryonal rhabdomyosarcoma. Through gaining a better understanding of the molecular causes for this impaired myogenic differentiation we want to support the development of therapies of rhabdomyosarcomas. Here, we focus on the induction of myogenic differentiation into postmitotic muscle cells.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Publications<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h3 class=\"wp-block-heading\">Selected Publications<\/h3>\n\n\n\n<p>Schmidt, M., Poser, C., Janster, C., and von Maltzahn, J. (2022). The hairpin region of WNT7A is sufficient for binding to the Frizzled7 receptor and to elicit signaling in myogenic cells. Comput Struct Biotechnol J <em>20<\/em>, 6348-6359. 10.1016\/j.csbj.2022.10.047.<\/p>\n\n\n\n<p>Schmidt, M., Weidemann, A., Poser, C., Bigot, A., and von Maltzahn, J. (2021). Stimulation of Non-canonical NF-kappaB Through Lymphotoxin-beta-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle. Front Cell Dev Biol <em>9<\/em>, 721543. 10.3389\/fcell.2021.721543.<\/p>\n\n\n\n<p>Schuler, S.C., Kirkpatrick, J.M., Schmidt, M., Santinha, D., Koch, P., Di Sanzo, S., Cirri, E., Hemberg, M., Ori, A., and von Maltzahn, J. (2021). Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality. Cell Rep <em>35<\/em>, 109223. 10.1016\/j.celrep.2021.109223.<\/p>\n\n\n\n<p>Schmidt, M., Poser, C., and von Maltzahn, J. (2020). Wnt7a Counteracts Cancer Cachexia. Mol Ther Oncolytics <em>16<\/em>, 134-146. 10.1016\/j.omto.2019.12.011.<\/p>\n\n\n\n<p>Ahrens, H.E., Huettemeister, J., Schmidt, M., Kaether, C., and von Maltzahn, J. (2018). Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle. Skelet Muscle <em>8<\/em>, 20. 10.1186\/s13395-018-0166-x.<\/p>\n\n\n\n<p>Mayerl, S., Schmidt, M., Doycheva, D., Darras, V.M., Huttner, S.S., Boelen, A., Visser, T.J., Kaether, C., Heuer, H., and von Maltzahn, J. (2018). Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration. Stem Cell Reports <em>10<\/em>, 1959-1974. 10.1016\/j.stemcr.2018.03.021.<\/p>\n\n\n\n<p>Lukjanenko, L., Jung, M.J., Hegde, N., Perruisseau-Carrier, C., Migliavacca, E., Rozo, M., Karaz, S., Jacot, G., Schmidt, M., Li, L., et al. (2016). Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med <em>22<\/em>, 897-905. 10.1038\/nm.4126.<\/p>\n\n\n\n<p>Schworer, S., Becker, F., Feller, C., Baig, A.H., Kober, U., Henze, H., Kraus, J.M., Xin, B., Lechel, A., Lipka, D.B., et al. (2016). Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature <em>540<\/em>, 428-432. 10.1038\/nature20603.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Link to Pubmed with all publications by J.v.Maltzahn <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=von+Maltzahn+J&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=von+Maltzahn+J&amp;sort=date<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Team<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\"><div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Anja Michelfeit\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/anja-michelfeit\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Anja Michelfeit<\/div>\n    <div class=\"about_person__position\">Assistant<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385812\" class=\"about_person__phone\">phone: +49 (0)3573 85 812<\/a><a href=\"mailto:anja.michelfeit@b-tu.de\" class=\"about_person__email\">anja.michelfeit[at]b-tu.de<\/a>  <\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Antje Muschter\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/antje-muschter\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Antje Muschter<\/div>\n    <div class=\"about_person__position\">Engineer<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385836\" class=\"about_person__phone\">phone: +49 (0) 3573 85 836<\/a><a href=\"mailto:Antje.muschter@b-tu.de \" class=\"about_person__email\">Antje.muschter[at]b-tu.de <\/a>  <\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Katja H\u00f6nzke\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/katja-honzke\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Katja H\u00f6nzke<\/div>\n    <div class=\"about_person__position\">Research Associate<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49 357385836\" class=\"about_person__phone\">phone: +49 (0) 3573 85 836<\/a><a href=\"mailto:Katja.hoenzke@b-tu.de \" class=\"about_person__email\">Katja.hoenzke[at]b-tu.de <\/a>  <\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Christiane Geithe\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/christiane-geithe\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Christiane Geithe<\/div>\n    <div class=\"about_person__position\">Research Associate<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385836\" class=\"about_person__phone\">phone: +49 (0) 3573 85 836<\/a><a href=\"mailto:christiane.geithe@b-tu.de \" class=\"about_person__email\">christiane.geithe[at]b-tu.de <\/a>  <\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Karolina Majchrzak\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/karolina-majchrzak\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Karolina Majchrzak<\/div>\n    <div class=\"about_person__position\">Research Associate<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385836\" class=\"about_person__phone\">phone: +49 (0) 3573 85 836<\/a><a href=\"mailto:Karolina.majchrzak@b-tu.de \" class=\"about_person__email\">Karolina.majchrzak[at]b-tu.de <\/a>  <\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"about_person\">\n  <div class=\"about_person__img\"><img decoding=\"async\" src=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/08\/person-fallback.jpg\" alt=\"Erik Hentschel\" \/><a href=\"https:\/\/www.fgw-brandenburg.de\/en\/person\/erik-hentschel\/\"><\/a><\/div>\n  <div class=\"about_person-content\">\n    <div class=\"about_person__name\">Erik Hentschel<\/div>\n    <div class=\"about_person__position\">Research Associate<\/div>\n    <div class=\"about_peersont__address\">\n    <\/div>\n<a href=\"tel:+49357385836\" class=\"about_person__phone\">phone: +49 (0) 3573 85 836<\/a><a href=\"mailto:Erik.hentschel@b-tu.de \" class=\"about_person__email\">Erik.hentschel[at]b-tu.de <\/a>  <\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prof. Dr. rer. nat. Julia von Maltzahn is FGW Professor for Stem Cell Biology of Aging at the Brandenburg University of Technology Cottbus-Senftenberg (BTU). The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging and during differentiation. Furthermore, they study the causes for impaired myogenic differentiation in &#8230;<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2481,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-6054","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stem Cell Biology of Aging | Faculty of Health Sciences<\/title>\n<meta name=\"description\" content=\"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging &amp; during differentiation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stem Cell Biology of Aging | Faculty of Health Sciences\" \/>\n<meta property=\"og:description\" content=\"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging &amp; during differentiation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/\" \/>\n<meta property=\"og:site_name\" content=\"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-16T06:52:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/\",\"url\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/\",\"name\":\"Stem Cell Biology of Aging | Faculty of Health Sciences\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/FGW_Stammzellbiologie_Muskelstammzellen.png\",\"datePublished\":\"2022-12-07T14:59:18+00:00\",\"dateModified\":\"2024-09-16T06:52:38+00:00\",\"description\":\"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging & during differentiation.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/FGW_Stammzellbiologie_Muskelstammzellen.png\",\"contentUrl\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/FGW_Stammzellbiologie_Muskelstammzellen.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/professorial-chairs\\\/stem-cell-biology-of-aging\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Members\",\"item\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/members\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Professorial chairs\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/\",\"name\":\"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften\",\"description\":\"FGW Brandenburg: Eine Fakult\u00e4t \u2013 drei Hochschulen.\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#organization\",\"name\":\"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften\",\"url\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/logo.png\",\"width\":552,\"height\":178,\"caption\":\"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften\"},\"image\":{\"@id\":\"https:\\\/\\\/www.fgw-brandenburg.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stem Cell Biology of Aging | Faculty of Health Sciences","description":"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging & during differentiation.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/","og_locale":"en_US","og_type":"article","og_title":"Stem Cell Biology of Aging | Faculty of Health Sciences","og_description":"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging & during differentiation.","og_url":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/","og_site_name":"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften","article_modified_time":"2024-09-16T06:52:38+00:00","og_image":[{"url":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/","url":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/","name":"Stem Cell Biology of Aging | Faculty of Health Sciences","isPartOf":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/#primaryimage"},"image":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/#primaryimage"},"thumbnailUrl":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png","datePublished":"2022-12-07T14:59:18+00:00","dateModified":"2024-09-16T06:52:38+00:00","description":"The research group stem cell biology of aging investigates alterations in muscle stem cell which occur during aging & during differentiation.","breadcrumb":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/#primaryimage","url":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png","contentUrl":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2022\/12\/FGW_Stammzellbiologie_Muskelstammzellen.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.fgw-brandenburg.de\/en\/members\/professorial-chairs\/stem-cell-biology-of-aging\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Start","item":"\/"},{"@type":"ListItem","position":2,"name":"Members","item":"https:\/\/www.fgw-brandenburg.de\/en\/members\/"},{"@type":"ListItem","position":3,"name":"Professorial chairs"}]},{"@type":"WebSite","@id":"https:\/\/www.fgw-brandenburg.de\/en\/#website","url":"https:\/\/www.fgw-brandenburg.de\/en\/","name":"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften","description":"FGW Brandenburg: Eine Fakult\u00e4t \u2013 drei Hochschulen.","publisher":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.fgw-brandenburg.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.fgw-brandenburg.de\/en\/#organization","name":"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften","url":"https:\/\/www.fgw-brandenburg.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fgw-brandenburg.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/05\/logo.png","contentUrl":"https:\/\/www.fgw-brandenburg.de\/wp-content\/uploads\/2021\/05\/logo.png","width":552,"height":178,"caption":"Fakult\u00e4t f\u00fcr Gesundheitswissenschaften"},"image":{"@id":"https:\/\/www.fgw-brandenburg.de\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/pages\/6054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/comments?post=6054"}],"version-history":[{"count":0,"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/pages\/6054\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/pages\/2481"}],"wp:attachment":[{"href":"https:\/\/www.fgw-brandenburg.de\/en\/wp-json\/wp\/v2\/media?parent=6054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}