For many years, the ageing cell has been a subject of research. Some mechanisms that contribute to the observed changes have already been identified. Nevertheless, there is still a considerable need for knowledge about the reaction of ageing cells.
New fields of research, such as stem cell research or epigenetics have been little studied with respect to their influence on the ageing process. What most of the processes known so far have in common is their influence on the expression of RNAs and thus on the protein levels and their reactions. Ageing processes were proved in all cell types of the body, and many processes, such as changed signal paths, show a common picture in the various organs.
These processes can therefore be studied in the most varied cell and tissue systems. Nevertheless, the aim is to identify common and organ-specific changes. 3D- cell models made of various cell types that better simulate the conditions within the organs in the body play a central role in this.